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10.1016/j.addr.2025.115572 45 MelmedS.PopovicV.BidlingmaierM.MercadoM.van der LelyA

The key to successful use of these drugs, says Dr Williams, is ongoing support, motivation and expertise to ensure that people do all of the right lifestyle and psychological interventions alongside the medication. The large landmark studies which initially proved the effectiveness of these drugs for weight loss all incorporated lifestyle advice and support, not just a leaflet as many online prescribers give.' Example exercise programme 'For people using GLP-1 medications, the goal is muscle preservation, metabolic protection and sustainability, not extreme calorie burn,' says Dr Ajaz

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