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A study of 31 men in 2018 found that taking ibuprofen (Aleve/Motrin) at a dose of 600mg twice a day showed alterations in their testicular-pituitary axis function resulting in hypogonadism (low testosterone), though the direct impact on semen parameters was not evaluated

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Since the discovery of FSP1, more and more GPX4-independent ferroptosis pathways have been discovered in various physiological and pathological processes Drugs targeting GPX4-independent ferroptosis pathway may become a new direction for the treatment of diseases

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