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Additionally, the issues of weight regain and altered metabolic outcomes following drug discontinuation emphasize the importance of long-term studies investigating the impacts of the hormonal and CNS on weight regain to optimize safety and efficacy [119,120]

Of note, to reduce the generation of mitochondrial ROS or to increase the scavenge of ROS similarly attenuate mitochondrial oxidative stress and kidney injury ( 3.2.1 Keap1-Nrf2-ARE signaling pathway activators 3.2.1.1 Epigallocatechin 3-Gallate (EGCG) EGCG, a bioactive constituent extracted from green tea, is widely investigated in various diseases, such as cardiovascular diseases, diabetes and cancer