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: Carnitine Deficiency in Chronic Kidney Disease: Pathophysiology, Clinical Implications, and Therapeutic Perspectives Yusuke Kaida et al

When purifying and separating curcuminoids from the oleoresin, volatile turmeric oil (CP-01) dissolves curcumin, causing issues with recrystallization

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The difference is small but important: AOD-9604 adds an N-terminal tyrosine for stability and has been tested in humans, while Fragment 176-191 is the unmodified parent sequence