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This significantly enhanced the accumulation of cisplatin in tumor cells, increasing efficacy in cisplatin resistant cells and decreased tossicity 95
Recently it was demonstrated that the sulfenic acid moiety in peroxiredoxin 6 was S-glutathionylated via glutathione S-transferase Pi (GSTP), indicating that a non-enzymatic reaction between sulfenic acid and GSH did not occur [60, 61]
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Hepatoprotective effect of rhein against methotrexate-induced liver toxicity
The convergence of these proposed mechanisms supports investigation into multi-layered signaling systems involved in cellular and tissue responses within controlled experimental settings
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