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An impaired UPS pathway is involved in multiple diseases, including cancer

In addition to sphingolipid synthesis, acid sphingomyelinase-mediated breakdown of sphingolipid is required for CD8 + T-cell-dependent clearance of LCMV infection in mice [268]

Thus, the development of additional therapeutic drugs including antidiabetics or IR interventions with beneficial effects against cognitive impairment and Alzheimers disease carry promising future application potentials

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Int Immunopharmacol 72:445453 Lin X et al (2020) Ameliorate effect of Pyrroloquinoline quinone against cyclophosphamide-induced nephrotoxicity by activating the Nrf2 pathway and inhibiting the NLRP3 pathway