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Clinical pharmacokinetics of new-generation antiepileptic drugs at the extremes of age: an update

Here, we extracted abundance and detergent solubility of extracellular antioxidant enzymes from a proteomic dataset of bleomycin-induced lung fibrosis in mice and assessed regulation and distribution of glutathione peroxidase 3 (GPX3) in murine and human lung fibrosis

A comprehensive monitoring strategy should begin with baseline assessments, including liver function tests (ALT, AST, ALP, and bilirubin), alongside a review of comedications to detect potential CYP3A4 inhibitors or OATP1B1 competitors that could elevate drug exposure

However, changes appear slowly and remain moderate

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