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But more than three decades ago, when Habener, Massachusetts General Hospital and Harvard Medical School investigator emeritus, set up an experiment that helped lead to the discovery, this outcome was far from clear

Options at that point may include switching medications, adding adjunctive therapy, investigating underlying conditions like hypothyroidism or PCOS, or reassessing whether this medication class is right for you

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However, only 24% of the participants in the intervention group maintained at least 10 kg weight loss, highlighting both the potential and the challenges of long-term durability of weight loss [89]

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