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[1] [2] Fatigue is listed as a common adverse reaction in the FDA prescribing information for Wegovy (semaglutide 2.4 mg for weight management), while it appears less prominently in the labeling for the diabetes formulations

Willingness to Commit to Lifestyle Changes: Semaglutide is most effective when combined with lifestyle modifications, including a reduced-calorie diet and increased physical activity

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This likely reflects dose differences rather than efficacy differences, but it definitively disproves the myth that diabetes is required for weight loss response