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Corticotroph adenomas express the somatostatin receptor (SSTR) subtype 5 (132) and ACTH secretion from cultured corticotroph adenomas is inhibited by pasireotide (133)
For instance, its action on ghrelin (the hunger hormone) does not cause hunger or increase other hormones like cortisol (the stress hormone) and prolactin
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The cardiometabolic benefits were consistently more pronounced in female participants, with women experiencing about a 5% reduction in total cholesterol versus 3% in men, and a 10% reduction in LDL cholesterol versus 4% in men
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