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Zhang L, Onda K, Imai R, Fukuda R, Horiuchi H, Ohta A

Recheck IGF-1 at 8 weeks to confirm sermorelin is producing the expected growth hormone response (a 3050% increase from baseline indicates adequate pituitary stimulation)

Cureus, 17(1), e78045

Verdict: Limited evidence the absence of human trials reflects a combination of a cancelled unpublished safety study, specific FDA-documented safety concerns, and structural barriers that make large-scale human trials difficult to initiate and fund [4][10][1415]

This evidence necessitates a paradigm shift from a one-size-fits-all supplementation approach to a genotype-stratified strategy, wherein GST status could be used to identify individuals most likely to benefit from SFN-based prevention