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found that 7-isopentenoxycoumarin significantly induced melanogenesis at a dose of 40 m, with the highest induction of melanin at 72 h, and excitingly the induction was 6-fold greater than that of the control group, and the mechanism of action was to increase melanogenesis by elevating MITF and its downstream genes tyrosinases, TRP-1 and Trp-2

Because it is potent at four subtypes and selective for none, MT-II serves three specific functions in the literature: as the positive-control full agonist against which candidate subtype-selective ligands are benchmarked in binding and cAMP accumulation assays

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Answer: Discontinuing glutathione may result in the gradual reestablishment of the skin's natural pigmentation, a decrease in antioxidant defenses, and potential effects on energy levels and immunity

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