If nothing has changed by week 3, the common next step is 2 mL or a move to daily 1 mL before deciding it does not work for you
In clinical trials (e.g., SURMOUNT-1), tirzepatide led to significant weight loss, an average weight loss of 15%20% of body weight over 72 weeks, when combined with diet and exercise
This is the first regulatory-level trial showing the benefit of semaglutide for people with MASH

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Some researchers try to compensate by injecting more, figuring that extra volume will offset potency loss