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While early demand for the oral version has been encouraging, it has yet to offset broader portfolio softness

Additionally, high levels of fumarate react with the cysteine group of mitochondrial aconitase-2 and iron-sulfur cluster binding protein-2, facilitating cellular metabolic adaptation to stresses 138

The peptide bonds in tirzepatide are sensitive to thermal fluctuation

Mean weight loss was 15.0% at 5 mg, 19.5% at 10 mg, and 20.9% at 15 mg

Phase 2 data published in the New England Journal of Medicine demonstrated substantial weight reduction in some participants exceeding 20% of body weight over 48 weeks alongside improvements in cardiometabolic markers