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3.3 Antioxidant interventions for the preservation of ovarian tissue and oocyte in the context of in vitro fertilization Oxidative stress triggers apoptosis in granulosa cells, leading to the upregulation of pro-apoptotic factors and the downregulation of anti-apoptotic proteins, ultimately causing ovarian tissue damage and follicular depletion ( Table 1 (82, 83)

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The survival rates at week 102 were 62%, 66%, and 84% in males (in controls, low-, and high-dose groups, respectively), and 66%, 50%, and 80% in females

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Life Sci 74:16351643 Jain SK (1985) In vivo externalization of phosphatidylserine and phosphatidylethanolamine in the membrane bilayer and hypercoagulability by the lipid peroxidation of erythrocytes in rats