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Astrocytes, emerging stars of energy homeostasis

Transdermal estradiol carries a lower risk of blood clots compared to oral formulations because it bypasses first-pass hepatic metabolism

603 Further studies have shown that ATP not only acts as an energy source to support regenerative repair but also functions as a purinergic signal, promoting liver regeneration in response to injury

Additionally, it has been reported that OS affects epigenetic regulatory mechanisms involved in the regulation of pancreatic cell survival and insulin secretion, like DNA methylation, chromatin architectural modification, and non-coding RNA (Kowluru and Mishra, 2017)