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Evidence of direct depletion: Weak Mechanistic plausibility via reduced intake: Moderate Symptoms of B12 Deficiency Neuropathy Fatigue Brain fog Macrocytic anaemia Persistent fatigue during GLP-1 therapy can have multiple causes, including caloric restriction and micronutrient shifts

The results align with the two semaglutide RCTs and with the exploratory obesity subgroup in the exenatide trial

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We gathered details including author names, publication dates, sample sizes, diagnostic criteria, intervention specifics (such as dose and treatment duration), and pertinent outcomes

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