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Description

Product Outline Product name: Rozebalamin for Injection 25 mg Generic name: Mecobalamin Indication for use: Slowing progression of functional impairment in amyotrophic lateral sclerosis Dosage and administration: The usual dose of mecobalamin in adults is 50 mg a day, twice a week, injected intramuscularly

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Gibbs DM, Vale W, Rivier J, Yen SS

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The palmitoyl group enables the peptide to penetrate much further into the skin compared to the unmodified peptide, allowing these benefits to reach the deeper layers of the skin

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Pretreatment with a Src inhibitor abolished these effects in HUVEC culture, placing Src upstream of the caveolin-1-eNOS step in the proposed cascade

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2020;182(6):1460-73.e17

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