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10.1016/j.isci.2023.106057 Summary Keywords drug mechanism, metformin, type 2 diabetes, gastrointestinal tract, gut microbiota Citation Cheng M, Ren L, Jia X, Wang J and Cong B (2024) Understanding the action mechanisms of metformin in the gastrointestinal tract

Protein is the most important macronutrient for weight maintenance after GLP-1 discontinuation, for three reasons

Bile acids trigger GLP-1 release predominantly by accessing basolaterally located G proteincoupled bile acid receptors. Endocrinology 156.11 (2015): 3961-3970

This class of prescription medications can help lower insulin secretion and delay gastric emptying

Note: these levels of per cent body weight reduction resemble what is typically achieved with the different types of bariatric surgery, such as gastric bypass