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The RLR family, comprising of RIG-I, melanoma differentiation-associated gene 5 (MDA5), and laboratory of genetics and physiology 2 (LGP2) plays a critical role in the innate response to viral infections and the production of type I IFN (113)

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The cytoplasmic chaperone Antioxidant 1 (ATOX1) then distributes copper to the ATP7A and ATP7B transporters in the trans-Golgi network for incorporation into cuproenzymes [91]