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Tonic inhibition An inhibitory signal that is thought to utilize extrasynaptic receptors (not directly apposed to presynaptic release sites), may be decoupled from presynaptic spiking and occurs over long (minutes or more) periods

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rather, its activity is mediated through modulation of multiple intersecting pathways

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However, do not discontinue prescribed B12 treatment without medical advice, particularly if you have pernicious anaemia or confirmed deficiency, as untreated B12 deficiency can lead to irreversible neurological damage