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In a systematic review, three-component Major Adverse Cardiovascular Events (3-p MACE) was reduced, with an HR of 0.86 (95% CI 0.800.92) for those over 65 years old, and there was an even more pronounced effect in those over age 75 (HR 0.75, 95% CI 0.610.92) (120)

Another study showed that acute administration of exenatide was associated with increased hepatic glucose uptake during an oral glucose tolerance test (OGTT) and a reduction in endogenous glucose production, reinforcing the hypothesis of a direct action of GLP-1 on the liver [12]

However, these changes in blood sugar and other metabolic processes can sometimes influence how often a person urinates

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Extreme cold can affect the stability and potency of the medication