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Among several possible prednisone side effects, Mayo Clinic cites these as ones you may be able to combat with diet changes: Weight gain High blood sugar High blood pressure Fluid retention Avoiding Weight Gain With Prednisone Prednisone, particularly in higher doses, can increase your appetite and may cause fat to be redistributed to the face, back of the neck, and the abdomen, according to the University of California San Francisco (UCSF) Health

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Significant appetite reduction occurs by weeks 3 to 4, when the medication reaches therapeutic levels in your system