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Impaired methylation can lead to elevated homocysteine concentrations and altered DNA methylation, both of which have been associated with an increased risk of cardiovascular disease, neurological disorders, and other chronic health conditions

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ORCID ID Taciana DalForno Dini: 0000-0003-0848-9042 Rafaela Malmann Saalfeld: 0009-0008-0157-0300 Clayton Luiz Dornelles Macedo: 0009-0006-9058-9147 Edileia Bagatin: 0000-0001-7190-8241 Research data availability The entire dataset supporting the results of this study was published in this article

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Nevertheless, previous long-term studies of TXNIP overexpression indicate persistent glucose dysregulation without affecting body weight 61 , supporting the physiological significance of TXNIP suppression for glucose homeostasis

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