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Methylcobalamin at the doses used (100 mcg) is extremely well tolerated and rarely causes adverse effects on its own

However, under conditions of iron overload, excess Fe 2+ in the LIP undergoes Fenton chemistry with H 2 O 2 , producing excessive ROS, promoting lipid peroxidation, and ultimately triggering ferroptosis (Zhao et al., 2025a)

Additionally, semaglutide maintains its activity in the body for a longer duration, effectively controlling food intake and stabilizing blood sugar levels

Pending the results of larger-scale clinical trials of GLP-1RAs already used in the clinic, the ongoing development of next-generation incretin mimetics opens up opportunities to improve their access to the brain and enhance neuroprotection [87]

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