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IGF-1 LR3 is an exogenous receptor agonist applied at the very endpoint of the axis, bypassing the feedback loop entirely

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Gastrointestinal Effects: - GI Issues: Persistent use can sometimes be associated with gastrointestinal side effects like nausea, vomiting, and diarrhea, although these side effects often diminish over time or with dose adjustment

Signal Transduct Target Ther 6(1):171 Sun Q, Wu J, Zhu G, Li T, Zhu X, Ni B et al (2023) Lactate-related metabolic reprogramming and immune regulation in colorectal cancer

Eighteen studies were identified describing ivermectin resistance in ectoparasites