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The hydrostatic pressure ensuing from kidney obstruction can trigger interstitial inflammatory infiltration, indicated mainly by increased numbers of tissue infiltrating-macrophages 48,51
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Less serious adverse effects include weight gain, acne, facial hair, and mood swings
Haslbeck KM, Neundorfer B, Schlotzer-Schrehardtt U, Bierhaus A, Schleicher E, Pauli E, Haslbeck M, Hecht M, Nawroth P, Heuss D: Activation of the RAGE pathway: a general mechanism in the pathogenesis of polyneuropathies
Both hyperglycemia and dyslipidemia can induce structural and functional damage in diabetic kidneys (Sun et al., 2019)
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