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Mean change in body weight from baseline to Week 52 was a secondary endpoint.* Statistically significant vs Januvia 100 mg PIONEER 3 study design 1,4 In a double-blind, double-dummy trial with a primary endpoint of mean change in A1C from baseline to 26 weeks, 1864 adult patients with type 2 diabetes on metformin alone or metformin with a sulfonylurea were randomized to RYBELSUS 3 mg (n=466), RYBELSUS 7 mg (n=465), RYBELSUS 14 mg (n=465), or Januvia 100 mg (n=467), all once daily

Subsequently, the islets were examined according to the steps outlined below for the functional analysis

doi: 10.3164/jcbn.12-122 49 KimSHKimSHLeeJHLeeBHYoonHJShinDHet al

Diabetes itself is a major risk factor for NAION