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Dose-finding study of subcutaneously administered BI 456906 for 16 weeks, compared with placebo and open-label semaglutide in patients with type 2 diabetes mellitus

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464 Furthermore, the generation of ROS can activate NRF2, leading to the transcriptional activation of Notch1 and Sonic Hedgehog, which in turn stimulates the Notch and Hedgehog signaling pathways