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In 1967, the Germans were the first to examine the relationship between nicotine and gastrointestinal disease after observing an increase in peptic ulcers in rats due to nicotine's increased gastric juice output

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Dependent smokers need nicotine to remain feeling normal

Lower price is one factor driving this, but so too are the quite erroneous beliefs that roll-your-own tobacco somehow contains fewer additives and is less harmful, an issue I will explore in my next column

Building a tolerance can cause long-term effects on the brain and body